Silexion Therapeutics (NASDAQ:SLXN – Get Free Report) and Apogee Therapeutics (NASDAQ:APGE – Get Free Report) are both small-cap medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their analyst recommendations, institutional ownership, dividends, risk, earnings, profitability and valuation.
Profitability
This table compares Silexion Therapeutics and Apogee Therapeutics’ net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Silexion Therapeutics | N/A | N/A | -249.43% |
| Apogee Therapeutics | N/A | -21.81% | -20.94% |
Earnings & Valuation
This table compares Silexion Therapeutics and Apogee Therapeutics”s gross revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Silexion Therapeutics | N/A | N/A | $260,000.00 | N/A | N/A |
| Apogee Therapeutics | N/A | N/A | -$83.99 million | ($3.29) | -12.07 |
Risk & Volatility
Silexion Therapeutics has a beta of 0.11, indicating that its stock price is 89% less volatile than the S&P 500. Comparatively, Apogee Therapeutics has a beta of 2.46, indicating that its stock price is 146% more volatile than the S&P 500.
Analyst Ratings
This is a summary of recent ratings and price targets for Silexion Therapeutics and Apogee Therapeutics, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Silexion Therapeutics | 0 | 0 | 1 | 0 | 3.00 |
| Apogee Therapeutics | 0 | 0 | 6 | 0 | 3.00 |
Silexion Therapeutics currently has a consensus target price of $5.00, suggesting a potential upside of 327.35%. Apogee Therapeutics has a consensus target price of $92.17, suggesting a potential upside of 132.04%. Given Silexion Therapeutics’ higher possible upside, research analysts clearly believe Silexion Therapeutics is more favorable than Apogee Therapeutics.
Insider & Institutional Ownership
10.9% of Silexion Therapeutics shares are held by institutional investors. Comparatively, 79.0% of Apogee Therapeutics shares are held by institutional investors. 33.0% of Silexion Therapeutics shares are held by company insiders. Comparatively, 36.1% of Apogee Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.
Summary
Apogee Therapeutics beats Silexion Therapeutics on 5 of the 8 factors compared between the two stocks.
About Silexion Therapeutics
Silexion Therapeutics LTD, a biopharmaceutical company, discovers and develops RNA interference (RNAi)-based cancer drugs and delivery systems to treat malignant solid tumors. The company engages in the treatment of solid tumors through its proprietary LODER delivery platform. Its products comprise SiG12D-LODER that has completed pre-clinical studies and an open label Phase I clinical trial for the treatment of pancreatic cancer; Prostate-LODER, which is in pre-clinical studies for the treatment of prostate cancer; and GBM-LODER that is in pre-clinical studies to target Glioblastoma Multiform, a malignant primary brain tumor. The company was founded in 2008 and is headquartered in Jerusalem, Israel.
About Apogee Therapeutics
Apogee Therapeutics, Inc., through its subsidiary, operates as a biotechnology company that develops biologics for the treatment of atopic dermatitis (AD), asthma, chronic obstructive pulmonary disease (COPD), and related inflammatory and immunology indications. The company primarily develops APG777, a subcutaneous (SQ) extended half-life monoclonal antibody (mAb) for AD; and APG808, an SQ extended half-life mAb for COPD. Its earlier-stage programs comprise APG990, an SQ extended half-life mAb for the treatment of AD; and APG222, an extended half-life SQ antibodies for AD. Apogee Therapeutics, Inc. was incorporated in 2022 and is headquartered in Waltham, Massachusetts.
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