X4 Pharmaceuticals (NASDAQ:XFOR – Get Free Report) and Tourmaline Bio (NASDAQ:TRML – Get Free Report) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their institutional ownership, profitability, dividends, valuation, analyst recommendations, risk and earnings.
Institutional and Insider Ownership
72.0% of X4 Pharmaceuticals shares are held by institutional investors. Comparatively, 91.9% of Tourmaline Bio shares are held by institutional investors. 1.6% of X4 Pharmaceuticals shares are held by insiders. Comparatively, 11.0% of Tourmaline Bio shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.
Earnings and Valuation
This table compares X4 Pharmaceuticals and Tourmaline Bio”s top-line revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| X4 Pharmaceuticals | N/A | N/A | -$101.17 million | ($0.09) | -5.19 |
| Tourmaline Bio | N/A | N/A | -$42.12 million | ($2.82) | -4.33 |
Risk and Volatility
X4 Pharmaceuticals has a beta of 0.12, meaning that its stock price is 88% less volatile than the S&P 500. Comparatively, Tourmaline Bio has a beta of 2.32, meaning that its stock price is 132% more volatile than the S&P 500.
Profitability
This table compares X4 Pharmaceuticals and Tourmaline Bio’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| X4 Pharmaceuticals | N/A | -236.19% | -75.14% |
| Tourmaline Bio | N/A | -20.97% | -20.56% |
Analyst Recommendations
This is a summary of recent recommendations and price targets for X4 Pharmaceuticals and Tourmaline Bio, as reported by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| X4 Pharmaceuticals | 0 | 0 | 3 | 0 | 3.00 |
| Tourmaline Bio | 0 | 0 | 6 | 0 | 3.00 |
X4 Pharmaceuticals presently has a consensus price target of $3.50, suggesting a potential upside of 649.30%. Tourmaline Bio has a consensus price target of $54.00, suggesting a potential upside of 342.26%. Given X4 Pharmaceuticals’ higher probable upside, equities analysts clearly believe X4 Pharmaceuticals is more favorable than Tourmaline Bio.
Summary
Tourmaline Bio beats X4 Pharmaceuticals on 8 of the 10 factors compared between the two stocks.
About X4 Pharmaceuticals
X4 Pharmaceuticals, Inc., a late-stage clinical biopharmaceutical company, focuses on the research, development, and commercialization of novel therapeutics for the treatment of rare diseases. Its lead product candidate is mavorixafor, a small molecule inhibitor of the chemokine receptor C-X-C chemokine receptor type 4 (CXCR4), which is in Phase III clinical trial for the treatment of patients with warts, hypogammaglobulinemia, infections, and myelokathexis syndrome; and Phase II clinical trial to treat congenital, idiopathic, or cyclic neutropenia. The company is also developing X4P-003, a CXCR4 antagonist for the treatment of CXCR4 dependent disorders and primary immunodeficiencies; and X4P-002, a CXCR4 antagonist for the treatment of blood-brain barrier diseases. It has a license agreement with Abbisko Therapeutics Co Ltd. to develop, manufacture, and commercialize mavorixafor in combination with checkpoint inhibitors or other agents in oncology indications. The company is headquartered in Boston, Massachusetts.
About Tourmaline Bio
Tourmaline Bio, Inc. operates as a clinical biotechnology company that develops medicines for patients with life-altering immune and inflammatory diseases. It develops TOUR006, a human anti-IL-6 monoclonal antibody that selectively binds to interleukin-6, a key proinflammatory cytokine involved in the pathogenesis of many autoimmune and inflammatory disorders. The company's development pipeline comprises medicines and therapies for the atherosclerotic cardiovascular disease (ASCVD) and thyroid eye disease (TED). The company was formerly known as Tourmaline Bio, LLC and changed its name to Tourmaline Bio, Inc. in September 2022. Tourmaline Bio, Inc. was founded in 2021 and is headquartered in New York, New York.
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